Antonio Valencia is set to return from a four-week absence with a hamstring injury as United look to overturn a 3-2 first-leg deficit in Spain.
The winger returned to full training on Monday and offers Sir Alex Ferguson a useful attacking option given Nani is among those who did not travel to northern Spain.
Phil Jones is also missing from the trip, in addition to Anderson, who is thought to have a hamstring injury, but Chris Smalling is available again after a head wound re-opened during last week's loss to the Spaniards at Old Trafford.
United (from): Amos, De Gea; Evans, Evra, Fabio, Ferdinand, Rafael, Smalling; Carrick, Cleverley, Giggs, Park, Pogba, Scholes, Young, Valencia; Berbatov, Hernandez, Rooney, Welbeck.