These are clubs in need of therapy at least as much as a place in the FA Cup semi-finals. Manchester United have lost two games in a row and Arsenal were knocked out of Europe. Both sides, though, are also competing for the Premier League title and any success in deepening the other's gloom would be welcomed. Arsenal's last victory at Old Trafford came in September 2006. Arsène Wenger's team will also have to shake off the despondency of Cesc Fábregas being sidelined by a recurrence of his hamstring injury. Kevin McCarra
Venue Old Trafford Tickets Sold out Best Cup run Manchester United (winners, 11) Arsenal (winners, 10) Referee C Foy Odds Manchester United 17-20 Arsenal 11-4 Draw 12-5
Man United
Subs from Kuszczak, Lindegaard, O'Shea, Berbatov, Brown, Fabio, Gibson, Owen, Hernández, Bébé
Injured Park (hamstring, 19 Mar), Ferdinand (calf, 19 Mar), Nani (gashed knee, 2 Apr), Valencia (broken leg, 2 Apr), Anderson (knee), Hargreaves (hamstring), Evans (ankle) – all unspecified Suspended None Form guide (all comps) LLWDWW Disciplinary record (all comps) Y54 R2 Leading scorer (all comps) Berbatov 20
Arsenal
Subs from Shea, Gibbs, Eboué, Squillaci, Denílson, Miquel, Rosicky, Chamakh Doubtful None Injured Song (knee, 19 Mar), Walcott (ankle, 19 Mar), Fábregas (hamstring, 26 Mar), Szczesny (finger, Apr), Frimpong (knee, May), Fabianski (shoulder, May), Vermaelen (achilles, unknown) Suspended NoneForm guide (all comps) LDWLWD Disciplinary record (all comps) Y76 R9 Leading scorer (all comps) Nasri, Van Persie 14
Match pointers
• Manchester United have won six of the 11 FA Cup matches they have played against Arsenal
• The visitors have scored only 15 times in their last 30 matches at Old Trafford
• Wayne Rooney missed a penalty when these teams met in December having scored in his previous two appearances against Arsenal
• United have conceded only eight goals in their last 15 FA Cup matches at home and not more than once in that run
• Arsenal lost the last time they faced United in this competition, a 4-0 fifth-round defeat in 2008