The 2-1 win against Rovers on Saturday evening fired the Red Devils eight points clear at the top of the Premier League table but left manager Sir Alex Ferguson bemoaning a lengthening injury list ahead of Tuesday's Champions League showdown with Jose Mourinho's side.
Nemanja Vidic is suspended and both Gary Neville and Wes Brown have already been ruled out. Now Ferguson seems certain to be without Evans, who limped off immediately after Cristiano Ronaldo's winner.
It means Ferguson is now crossing his fingers that John O'Shea recovers from a sore heel in time to play against Jose Mourinho's side at the San Siro.
"It is a nightmare," admitted the United chief.
"Somewhere I have to find two centre-backs but it is looking very doubtful because Jonny is unlikely to play now."
If O'Shea does not make it, Ferguson faces the uncomfortable prospect of calling up reserve team rookie James Chester or playing one of his more experienced players out of position.