Manchester United expect Rio Ferdinand, Carlos Tevez and Wes Brown to have shaken off minor knocks.
Park Ji-sung is unlikely to figure, having this week missed a reserve-team game against Oldham, but he is expected to feature over the festive period.
Tim Howard, Ayegbeni Yakubu, Mikel Arteta, Tim Cahill and Joseph Yobo could all return for Everton after being rested against AZ Alkmaar.
Everton will be without Leon Osman, Alan Stubbs and Leighton Baines.
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Man Utd team : Van der Sar, Kuszczak, Brown, O'Shea, Ferdinand, Vidic, Pique, Evra, Fletcher, Ronaldo, Nani, Carrick, Anderson, Hargreaves, Park, Giggs, Saha, Rooney, Tevez.
Everton team : Howard, Wessels, Neville, Hibbert, Yobo, Jagielka, Lescott, Valente, Pienaar, Carsley, Arteta, Cahill, Gravesen, McFadden, Yakubu, Johnson, Anichebe, Vaughan.
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Manchester United boss Sir Alex Ferguson:"Everton have done exceptionally well this season and David Moyes takes all the credit for that. "It is a young team with a future which augurs well for Everton. They will be a handful and we'll need our best form. "David has put youngsters on long-term contracts to keep some continuity and made some good buys to strengthen."
Everton midfielder Mikel Arteta:"We are on a very good run and must try to enjoy it. "Old Trafford is my favourite away ground, they are always very hard games but we'll try to get something from it. "I love Cristiano Ronaldo, his development has been unbelievable. He handles pressure so well and is improving all the time."