Brazilian international Anderson will get a run-out for United's Reserves against Manchester City on Tuesday evening.
The 19-year-old summer signing from Porto made his senior debut against Sunderland on Saturday, and Sir Alex Ferguson has taken the decision to give him more playing time at Sports City.
Anderson will play upfront with Fraizer Campbell as the Reds look to build on last Thursday's opening-game win over Everton at the Victoria Stadium.
Febian Brandy - the Reds' matchwinner against the Toffees - will again be on the bench as Brian McClair and Jim Ryan name another strong side for Tuesday's derby.
Tom Heaton continues in goal, behind a back four of Phil Bardsley, James Chester and Eckersley brothers Richard and Adam.
A particularly strong Reds midfield comprises wingers Chris Eagles and Lee Martin, either side of Sam Hewson and Kieran Lee in the centre.
Dong Fangzhuo drops to the bench, alongside Brandy, Sean Evans, Michael Barnes and goalkeeper Gary Woods.
United: Heaton; R Eckersley, Bardsley, Chester, A Eckersley; Eagles, Hewson, Lee, Martin; Anderson, Campbell.
Substitutes: Dong, Woods, Barnes, Brandy, S Evans.